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College Football · Week 3 Odds & Lines

Every ranked line on the Week 3 board — and the four bets we'd make.

Spreads and totals for the whole ranked slate, from a top-10 pick'em in Oxford to a Friday-night Big 12 fight, plus the four against-the-spread plays we like best. Want the storylines? Start with the full Week 3 preview.

4 BetsThe card

What we like most

LSU +3 at Ole Miss. North Carolina +3.5 at Clemson. Houston +7.5 at Texas Tech. Florida State +20.5 at Alabama. Take the points in the four spots where the market is shortest — reasoning below.

Best bets at a glance

Week 3 is the first Saturday that actually prices talent instead of buy games, and the board reflects it: a genuine top-10 pick'em, two more ranked-vs-ranked lines, and a stack of top-five teams laying three and four touchdowns. Here's the whole ranked slate, then the four numbers we'd actually bet.

The full ranked & marquee board

Spreads and totals from bet365 as published by CBS Sports, as of Friday, Sept. 19. Times ET.

GameLineTotal
No. 5 Miami at Wake Forest (Fri)Miami -2155.5
No. 22 Houston at No. 13 Texas Tech (Fri)Texas Tech -7.553.5
No. 2 Georgia at ArkansasGeorgia -25.554.5
North Carolina at ClemsonClemson -3.544.5
No. 6 Ohio State vs Kent StateOhio State -52.558.5
No. 14 Penn State vs BuffaloPenn State -39.548.5
Florida State at No. 10 AlabamaAlabama -20.549.5
Kentucky at No. 9 Texas A&MTexas A&M -16.549.5
No. 16 SMU at No. 23 LouisvilleLouisville -1.559.5
No. 12 USC at RutgersUSC -23.559.5
No. 4 Indiana vs Western KentuckyIndiana -44.560.5
No. 17 Utah vs Utah StateUtah -2856.5
No. 18 Iowa vs Northern IowaIowa -31.548.5
No. 19 Michigan vs UTEPMichigan -35.548.5
Mississippi State at South CarolinaSouth Carolina -3.558.5
No. 20 Missouri vs TroyMissouri -27.550.5
Michigan State at No. 3 Notre DameNotre Dame -29.552.5
New Mexico at No. 24 OklahomaOklahoma -22.548.5
No. 7 LSU at No. 8 Ole MissOle Miss -359.5
West Virginia vs No. 25 VirginiaVirginia -1053.5
No. 1 Texas vs UTSATexas -29.552.5

The four bets we'd make

1. LSU +3 at Ole Miss

A three-point line between top-10 teams is the market saying the rosters are even and the home field is the whole margin. We'll take the points with the team that has the extra motivation — Lane Kiffin walking back into the building he built — and the belief that a coach knows the personnel he's facing better than anyone. In a game the books think is a coin flip, always rather have the field goal than lay it.

2. North Carolina +3.5 at Clemson

The most informative short line on the board. When a program with Clemson's ceiling can only lay a field goal and a half at home against an unranked opponent, the market is quietly flashing a warning. We'll take the points and the possibility of an outright upset in a game the number says is nearly even.

3. Houston +7.5 at Texas Tech

A ranked road dog getting more than a touchdown on a Friday night is exactly the kind of spot where the spread overshoots the storyline. Texas Tech is the trendier team, which is often how the favorite gets inflated. Give us the ranked underdog and the points.

4. Florida State +20.5 at Alabama

Three touchdowns is a heavy number in a game the total (49.5) says won't be a shootout, and Alabama in a "bounce-back" spot is priced for style points it doesn't always deliver. Take the points with a Florida State side that only has to keep it respectable to cash.

Totals worth a lookTwo games share the weekend's top number at 59.5: LSU–Ole Miss and SMU–Louisville. If you're a totals bettor, the LSU–Ole Miss under is the more interesting side — two defenses that big rivalry games tend to tighten, and a number the market set high on reputation.
Our lean, in one linePoints in every short spot — LSU, North Carolina, Houston, Florida State — because Week 3 is when the market overpays for early-season reputation and undervalues the teams still proving it. Flat stakes, live numbers, no chasing.

For the matchups behind these numbers, read the full College Football Week 3 preview.

Analysis & opinion — not betting advice. Picks are our opinion for entertainment. Betting lines are from bet365 as published by CBS Sports as of Friday, September 19, 2026, and change constantly; confirm the current number with your sportsbook before wagering. Must be 21+ where legal. Bet what you can afford to lose. If you or someone you know has a gambling problem, call 1-800-GAMBLER.